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01

LungUltrasoundtoPhenotypeChronicLungAllograftDysfunctioninLungTransplantRecipients.AProspectiveObservationalStudy

JesperR?mhildDavidsen,ChristianBLaursen,MikkelH?jlund5,ThomasKromannLund6,KlausNielsenJeschke7,MartinIversen6,AnnaKalhauge8,ElisabethBendstrup9,J?rnCarlsen,MichaelPerch,DanielPilsgaardHenriksen5,HansHenrikLawaetzSchultz6

1SouthDanishCenterforInterstitialLungDiseases(SCILS),OdenseUniversityHospital,Odense,Denmark.

2DepartmentofRespiratoryMedicine,OdenseUniversityHospital,Odense,Denmark.

3OdenseRespiratoryResearchUnit(ODIN),DepartmentofClinicalResearch,UniversityofSouthernDenmark,Odense,Denmark.

4OdensePatientDataExplorativeNetwork,OdenseUniversityHospital,Odense,Denmark.

5DepartmentofClinicalBiochemistryandPharmacology,OdenseUniversityHospital,Odense,Denmark.

6DepartmentofCardiology,SectionforLungTransplantation,CopenhagenUniversityHospital,Rigshospitalet,Copenhagen,Denmark.

7DepartmentofRespiratoryMedicine,CopenhagenUniversityHospital,HvidovreHospital,Hvidovre,Denmark.

8DepartmentofRadiology,CopenhagenUniversityHospital,Rigshospitalet,Copenhagen,Denmark.

9CenterforRareLungDiseases,DepartmentRespiratoryDiseasesandAllergy,AarhusUniversityHospital,Aarhus,Denmark.

10DepartmentofClinicalMedicine,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark.

Background/p>

Bronchiolitisobliteranssyndrome(BOS)andrestrictiveallograftsyndrome(RAS)aretwodistinctphenotypesofchroniclungallograftdysfunction(CLAD)inlungtransplant(LTx)recipients.ContrarytoBOS,RAScanradiologicallypresentwithapleuroparenchymalfibroelastosis(PPFE)pattern.Thisstudyinvestigateslungultrasound(LUS)toidentifypotentialsurrogatemarkersofPPFEinordertodistinguishCLADphenotypeRASfromBOS.

Methods/p>

AprospectivecohortstudyperformedataNationalLungTransplantationCenterduringJunetoDecember.PatientswereexaminedwithLUSandhigh-resolution

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